ACUTE LEUKEMIA BEFORE AND AFTER CHEMOTHERAPY WITH RESPECT TO LIVER FUNCTION TESTS
Keywords:
Alanine Transaminase (ALT), Aspartate Transaminase (AST), Bilirubin, Acute Leukemia , before and after Chemotherapy, Liver Function Tests and chemotherapy.Abstract
Background: Chemotherapeutic agents can cause hypersensitivity reactions or direct hepatic toxicity, while altered liver function can change drug metabolism and increase the risk of non-hepatic toxicity.
Methodology: Serum total bilirubin was measured with the DMSO method, while serum AST and ALT were measured using the kinetic method before and after chemotherapy doses.
Results: The results found that chemotherapy-induced hepatotoxicity in patients with acute leukaemia.
Conclusions: This study concluded that chemotherapeutic drugs cause an increase in serum total bilirubin, ALT, and AST during the treatment of acute leukaemia. Liver function tests should be performed on a regular basis while treating leukaemia patients.
